ATP-polyamine-biotin (Cat.#:AYB26708)
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Biological activity
Information
Biological activity
| Bioactivity | ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells. | ||||||||||||||||
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| CAS | 1800401-93-7 | ||||||||||||||||
| Chinese name | ATP多胺生物素 | ||||||||||||||||
| Mol.Wt. | 945.85 | ||||||||||||||||
| In vitro | ATP-polyamine-biotin (APB) is incubated with PKA kinase and full-length protein substrate, myelin basic protein (MBP). Biotinylation was observed only in presence of kinase. In addition, MBP biotinylation was lost in the absence of ATP-polyamine-biotin, in presence of the kinase inhibitor staursporine or upon incubation with acid due to cleavage of phosphoramidate bond. Biotinylated kemptide product is observed only in the presence of APB cosubstrate. The accuracy of these methods have not been independently confirmed. They are for reference only. |
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| Format | Solid | ||||||||||||||||
| Transportation | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| Storage | 4°C, protect from light | ||||||||||||||||
| Solubility | In Vitro: H2O : 6 mg/mL (6.34 mM; Need ultrasonic and warming) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。 |
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| Purity | 99.63% |
Information
| Intro | ATP-polyamine-biotin，是第一种可透过细胞的 ATP 类似物，是一种有效的激酶共底物。ATP-polyamine-biotin 可促进活细胞中激酶底物的生物素标记。 |
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| Synonym | ATP多胺生物素 |
| Rela_targets | Bioactive Compound Library Plus |