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ABI2 (YD13466) Rabbit mAb  (Cat.#:AYD16171)

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Host: RabbitClonality: MonoclonalReactivity: Human, Mouse, RatIHC-PICC/IF
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Cat.# AYD16171
Target / gene ABI2
Host Rabbit
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Application IHC-P, ICC/IF

Cat.#：AYD16171

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50ul RMB: 680Sale1280 Add to cart
100ul RMB: 1219Sale2300 Add to cart

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  • Information

  • Application guide

  • Related products

  • Immunogen

  • Target data

  • Resources

  • FAQs

Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Isotype IgG
Application IHC-PICC/IF
Dilution
Predicted MW 56kDa
Observed MW
Format Liquid
Storage Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3.
Conjugate Unconjugated
Positive U-251MG,Mouse brain
Subcellular Cytoplasm, Nucleus, Cell projection, lamellipodium, filopodium, cytoskeleton, Cell junction, adherens junction
Purification 亲和纯化

Applications and conditions

Where to start

These starting conditions come from the recommended dilution, validation images, and general assay practice. Titrate for your sample and detection system.

IHC-P Conditions for IHC-P
Recommended dilution See the validation images or contact technical support
Suggested sample / positive control U-251MG,Mouse brain
Key conditions For paraffin sections, optimize retrieval buffer pH, retrieval time, and primary incubation
Expected result Expected localization: Cytoplasm, Nucleus, Cell projection, lamellipodium, filopodium, cytoskeleton, Cell junction, adherens junction
Controls Include a positive sample, a negative sample, and a secondary or isotype control
ICC/IF Conditions for ICC/IF
Recommended dilution See the validation images or contact technical support
Suggested sample / positive control U-251MG,Mouse brain
Key conditions Optimize fixation, permeabilization, and blocking, and include a secondary-only control
Expected result Expected fluorescence localization: Cytoplasm, Nucleus, Cell projection, lamellipodium, filopodium, cytoskeleton, Cell junction, adherens junction
Controls Include a positive sample, a negative sample, and a secondary or isotype control

Related products

More associated products >>
ABI2 Rabbit mAb
Same target
AYM30952
ABI2 Rabbit mAb
WB,IHC,IF/ICC

Immunogen

Immunogen Please contact Support
Sequence Request sequence

Target data

Background Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity. Also required for nascent adherens junction assembly in epithelial cells.
Gene ID 10152
Gene name ABI2
Swiss Q9NYB9
Synonym ABI2 (YD13466),ABI2 (YD13466) Rabbit mAb,ABI2,Abelson interactor 2,Abl-binding protein 3,Arg-binding protein 1,ARGBPIA

Resources

Validation data

1 images

Validation images at the top of the page cover IHC-P / ICC/IF.

References

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FAQs

Listed applications: IHC-P, ICC/IF. Use the validation images and recommended dilution as a starting point.
Send the catalog number and lot through the inquiry form. Support will help with the lot documents.
Use the recommended conditions as a starting concentration. Sample, fixation, and detection system may need a titration.
AYD16171