目录号:B28148
生物活性: Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial therapy for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
CAS: 216596-71-3
中文名称:N-十一烷酰基-L-高丝氨酸内酯
目录号:B27416
生物活性: Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial therapy for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
CAS: 479050-96-9
中文名称:十八酰基 -L-高丝氨酸内酯
目录号:B27586
生物活性: 18:0-18:2 PE is a lipid for drugs delivering. 18:0-18:2 PE is mainly composed of unsaturated fatty acids. 18:0-18:2 is considered important precursors of important odorants (IOs) in Eriocheir sinensis.
CAS: 7266-53-7
目录号:B27916
生物活性: Hyodeoxycholic acid sodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 10421-49-5
中文名称:酒溶锁阳提取物
目录号:B28330
生物活性: Dehydroergosterol is a naturally occurring fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes. [1] It is readily bound by cholesterol-binding proteins and has been used to probe the sterol environment in real time and elucidate intracellular sterol transport in organisms. [1] References: [1]. McIntosh, AL, Atshaves, BP, Huang, H., et al. A Fluorescent Technique to Study Cholesterol Transport Using Dehydroergosterol. Lipids 43(12), 1185-1208 (2008).
CAS: 516-85-8
中文名称:去氢麦角甾醇
目录号:B26694
生物活性: Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
CAS: 596-09-8
中文名称:荧光素二乙酸酯
目录号:B26902
生物活性: Acetylcholinesterase (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses, and is often used in biochemical research. Acetylcholinesterase catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors.
CAS: 9000-81-1
目录号:B27131
生物活性: N-Palmitoyl phosphatidylethanolamine (Tripelargonin) is endogenous lipid anorectic hormone, significantly reduces food intake in a dose-dependent manner
CAS: 108321-22-8
目录号:B27991
生物活性: Glycerol-d8 is the deuterium labeled Glycerol[1].
CAS: 7325-17-9
中文名称:甘油-d8(99%)
目录号:B28383
生物活性: Orange G is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 1936-15-8
中文名称:酸性橙GG
