目录号:B27416
生物活性: Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial therapy for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
CAS: 479050-96-9
中文名称:十八酰基 -L-高丝氨酸内酯
目录号:B27468
生物活性: L-Iditol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 488-45-9
中文名称:化合物 T20399
目录号:B27916
生物活性: Hyodeoxycholic acid sodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 10421-49-5
中文名称:酒溶锁阳提取物
目录号:B27982
生物活性: L-Altrose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 1949-88-8
中文名称:L(-)-阿卓糖
目录号:B28052
生物活性: 4-(2-Pyridylazo)resorcinol monosodium salt is a useful research compound.
CAS: 16593-81-0
中文名称:4-（2-吡啶偶氮）间苯二酚单钠盐
目录号:B28121
生物活性: D(+)-Altrose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 1990-29-0
中文名称:D-ALTROSE D-阿卓糖
目录号:B28144
生物活性: N-Benzoyl-D-glucosamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 655-42-5
中文名称:2-苯甲酰胺基-2-脱氧-D-吡喃葡萄糖
目录号:B28293
生物活性: Diiodofluorescein disodium salt is a dye.
CAS: 33239-19-9
中文名称:4,5-二碘荧光黄
目录号:B26694
生物活性: Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
CAS: 596-09-8
中文名称:荧光素二乙酸酯
目录号:B26697
生物活性: Imidazole is a planar 5-membered ring. Imidazole is a highly polar compound. Imidazole has been used extensively as a corrosion inhibitor. Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Imidazole is useful as a buffer in the pH range of 6.2-7.8 One of the applications of imidazole is in the purification of His-tagged proteins in immobilised metal affinity chromatography(IMAC). Imidazole is used to elute tagged proteins bound to Ni ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel co-ordination, freeing the His-tagged proteins. Imidazole has become an important part of many pharmaceuticals. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, which stimulates the central nervous system. It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities.
CAS: 288-32-4
中文名称:咪唑
