目录号:B27704
生物活性: Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. [1] [2] Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. [3] 5β,6β-epoxycholestanol has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue. [4] References: [1]. Pulfer, MK, and Murphy, RC Formation of bioactive oxygen sterols during ozonolysis of cholesterol present in lung surfactants. Journal of Biochemistry 279(25), 26331-26338 (2004). [2]. Aringer, L. and Eneroth, P. In vitro formation and metabolism of cholesterol and β-sitosterol 5,6-epoxides. J. Lipid Research. 15(4), 389-398 (1974).[3]. Lordan, S., O'Brien, NM, and Mackrill, JJ Calcium in 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide-induced apoptosis. J. Biochemistry. Moore. poison. 23(5), 324-332 (2009).[4]. Garcia-Cruset, S., Carpenter, KL, Guardiola, F. et al. Oxysterol profiles of normal human arteries, fatty streaks, and advanced lesions. free radicals. reservoir. 35(1), 31-41 (2001).
CAS: 4025-59-6
中文名称:5Β,6Β-环氧胆甾醇
目录号:B27206
生物活性: Taurohyodeoxycholic acid sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. 1 THDCA reduces the size and weight of human gallstones in vitro. It increases bile flow, bile cholesterol secretion and bile lipid secretion in rats. 2 Co-administration of THDCA and taurochenodeoxycholic acid prevented TCDCA-induced hepatotoxicity and increased bile flow and bile acid and phospholipid secretion in rats. 3 THDCA can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model. 41. Angelico, M., Mogavero, L., Baiocchi, L., et al. Dissolution of human cholesterol bile salts/lecithin mixtures for gallstones: effects of bile salt hydrophobicity and various pHsScand. J. Gastroenterol.30(12)1178-1185(1995) 2.Angelico, M., Baiocchi, L., Nistri, A., et al.Effect of taurohodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid 2. Angelico, M., Baiocchi, L., Nistri, A., et al. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretions in rats. Sci.39(11)2389-2397(1994) 3.Roda, A., Piazza, F., Baraldini, M., et al.Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rataHepatology27(2)520-525 (1998) 4.He, J., Liang, J., Zhu, S., et al. Protective effect of pig powder taurine hyodeoxycholic acid on trinitrobenzenesulfonic acid-induced ulcerative colitis in mice Eur . J. Pharmacol. 670(1) 229-235(2011)
CAS: 38411-85-7
中文名称:牛磺猪去氧胆酸钠(SIGMA分装)
目录号:B27417
生物活性: Lithocholic acid 3-sulfate disodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 64936-81-8
中文名称:钠(3ALPHA,5BETA)-3-(磺酸氧基)胆烷-24-酸酯水合物(2:1:1)
