ABI2 (YD13466) Rabbit mAb (货号:AYD16171)
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产品信息
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抗原信息
靶点信息
| 反应 | Human, Mouse, Rat |
|---|---|
| 宿主 | Rabbit |
| 克隆性 | Monoclonal |
| 应用 | IHC-PICC/IF |
| 推荐浓度 | |
| 理论分子量 | 56kDa |
| 实测分子量 | |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3. |
| 偶联物 | Unconjugated |
| 阳性对照 | U-251MG,Mouse brain |
| 细胞定位 | Cytoplasm, Nucleus, Cell projection, lamellipodium, filopodium, cytoskeleton, Cell junction, adherens junction |
| 纯化 |
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抗原信息
| 抗原信息 | 请咨询 技术支持 |
|---|---|
| 序列 | Email For Sequence |
靶点信息
| 研究背景 | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity. Also required for nascent adherens junction assembly in epithelial cells. |
|---|---|
| 基因 ID | 10152 |
| 基因名 | ABI2 |
| Swiss | Q9NYB9 |
| 别名 | ABI2 (YD13466) |