ABCE1 Rabbit mAb  (货号:B29774)

说明书

货号:B29774

规格价格
50ul ¥1080.00 加购物车
100ul ¥2050.00 加购物车
反应 Human,Mouse,Rat
宿主 Rabbit
克隆性 Monoclonal
应用 WBIHCIF/ICCIPFC
推荐浓度 WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF/ICC: 1:50 - 1:200
IP: 1:20 - 1:50
FC: 1:20 - 1:50
理论分子量 67kDa
实测分子量 67kDa
形式 Liquid
保存条件 Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3.
偶联物 Unconjugated
阳性对照 HeLa,HT-29,K-562,Mouse liver,Mouse spleen,Mouse pancreas
细胞定位 Cytoplasm,Mitochondrion
纯化 Affinity purification

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抗原信息

抗原信息 Recombinant fusion protein.
序列 Email For Sequence

靶点信息

研究背景 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
基因ID 6059
基因名 ABCE1
Swiss P61221
别名 ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI; RNS4I
功能 Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.

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实验步骤

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