GPCRs and small G proteins relay ligand cues into intracellular second-messenger systems.
AblyBio · Research Areas
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Signal transduction converts extracellular cues into intracellular responses that drive proliferation, differentiation, metabolism, and survival. AblyBio covers G-protein and kinase families plus core pathways such as PI3K-Akt, mTOR, MAPK, and ErbB for mechanistic and interventional studies.
GPCRs and small G proteins relay ligand cues into intracellular second-messenger systems.
Ser/Thr and tyrosine kinase cascades amplify and branch signals that choose cell fate.
PI3K-Akt-mTOR and MAPK families integrate nutrient, growth, and stress inputs.
Mechanistic highlights and entry points for your research
From membrane receptors through cytosolic cascades to nuclear transcription, signaling networks use multi-level feedback to keep homeostasis. GPCRs, receptor tyrosine kinases, Ser/Thr kinases, and lipid messengers together decode environmental information.
PI3K-Akt-mTOR, MAPK (Erk/JNK/p38), ErbB-HER, ATM, and EGF pathways recur across development and disease; their aberrant activation or inhibition underpins many targeted therapies.
Browse by pathway to assemble detection panels from receptors to downstream effectors.
Drill into mechanisms and targets to find matching antibodies
Validated antibodies for this research area across WB, IHC, IF and more
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