AblyBio · Research Areas

Signal Transduction

信号转导

Signal transduction converts extracellular cues into intracellular responses that drive proliferation, differentiation, metabolism, and survival. AblyBio covers G-protein and kinase families plus core pathways such as PI3K-Akt, mTOR, MAPK, and ErbB for mechanistic and interventional studies.

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Theme Receptors & G Proteins

GPCRs and small G proteins relay ligand cues into intracellular second-messenger systems.

Theme Kinase Cascades

Ser/Thr and tyrosine kinase cascades amplify and branch signals that choose cell fate.

Theme Growth & Stress Pathways

PI3K-Akt-mTOR and MAPK families integrate nutrient, growth, and stress inputs.

Overview

Mechanistic highlights and entry points for your research

From membrane receptors through cytosolic cascades to nuclear transcription, signaling networks use multi-level feedback to keep homeostasis. GPCRs, receptor tyrosine kinases, Ser/Thr kinases, and lipid messengers together decode environmental information.

PI3K-Akt-mTOR, MAPK (Erk/JNK/p38), ErbB-HER, ATM, and EGF pathways recur across development and disease; their aberrant activation or inhibition underpins many targeted therapies.

Browse by pathway to assemble detection panels from receptors to downstream effectors.