Enzymes that write and erase phospho-marks set the on/off state and strength of signaling.
AblyBio · Research Areas
蛋白质磷酸化
Protein phosphorylation is among the most common and reversible post-translational modifications in cell signaling, balanced by kinases and phosphatases. AblyBio offers validated antibodies to phospho-sites, kinases, and pathway nodes for signaling network and drug-target research.
Enzymes that write and erase phospho-marks set the on/off state and strength of signaling.
Antibodies to key phospho-sites report pathway activation by WB, IHC, IF and related assays.
Dysregulated phospho-networks drive proliferation, survival and metabolic rewiring—key therapeutic entry points.
Mechanistic highlights and entry points for your research
Serine, threonine, and tyrosine phosphorylation rapidly reshape protein conformation, localization, activity, and interactions, letting cells respond to growth factors, stress, and metabolic cues on millisecond-to-minute timescales.
Phospho-signaling threads through MAPK, PI3K-Akt, mTOR, ATM and related pathways; its dysregulation is central to cancer, metabolic disease, and neurodegeneration. Mapping phosphorylation events underpins mechanistic studies and targeted therapy development.
Browse antibodies in this area, or pair with related topics such as signal transduction to build complete assay panels.
Validated antibodies for this research area across WB, IHC, IF and more
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