N-Stearoyl Phytosphingosine (Cat.#:AYB27862)
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Biological activity
Information
Biological activity
| Bioactivity | C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation. |
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| CAS | 34354-88-6 |
| Chinese name | N-硬脂酰基植物鞘氨醇 |
| Mol.Wt. | 583.97 |
| Transportation | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Information
| Intro | C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) 是一种生物活性鞘脂，存在于酿酒酵母、小麦籽粒和哺乳动物表皮的角质层中。 Cer(t18:0/18:0) 由植物鞘氨醇主链胺连接到 C18 脂肪酸链组成。 Cer(t18:0/18:0) 具有调节细胞凋亡、细胞分化、平滑肌细胞增殖和抑制线粒体呼吸链的作用。它还抑制组蛋白刺激的小鼠皮肤组织中过敏性细胞因子 IL-4、TNF-α 以及转录因子 c-Jun 和 NF-κB 的表达。含有 cer(t18:0/18:0) 的配方已被用作化妆品中的皮肤保护剂，因为它们可以减少水分流失，防止表皮脱水和刺激。 |
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| Synonym | N-(octadecanoyl)-4R-hydroxysphinganine,N-硬脂酰基植物鞘氨醇 |