Lipid 5 (Cat.#:AYB26702)
Biological activity
Information
Biological activity
| Bioactivity | Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects. | ||||||||||||||||
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| CAS | 2089251-33-0 | ||||||||||||||||
| Mol.Wt. | 710.17 | ||||||||||||||||
| In vitro | Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid. The accuracy of these methods have not been independently confirmed. They are for reference only. |
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| Format | Liquid | ||||||||||||||||
| Transportation | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| Solubility | In Vitro: DMSO : 100 mg/mL (140.81 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。 |
Information
| Intro | Lipid 5 是一种氨基脂质,可在啮齿动物和灵长类动物模型中提供有效的 mRNA 递送。Lipid 5 显示出最佳的药代动力学和无毒副作用。 |
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| Rela_targets | Bioactive Compound Library Plus Lipid Compound Library |
