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IgG1 (YD34110) Rabbit mAb  (Cat.#:AYD11644)

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Host: RabbitClonality: MonoclonalReactivity: Mouse, RatELISA
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货号 AYD11644
靶点/基因 Ighg1
宿主 Rabbit
克隆性 Monoclonal
反应种属 Mouse, Rat
应用 ELISA

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Cat.#：AYD11644

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50ul ￥1280.00 AddToCart
100ul ￥2300.00 AddToCart

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  • Immunogen

  • Target data

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Reactivity Mouse, Rat
Host Rabbit
Clonality Monoclonal
同种型 IgG
Application ELISA
Dilution
Predicted MW 36kDa
Observed MW
Format Liquid
Storage Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3.
Conjugate Unconjugated
Positive
Subcellular Secreted
Purification 亲和纯化

应用与推荐条件

快速判断怎么用

以下条件基于推荐浓度、验证图说明与通用实验要求整理，可作为预实验起点；不同样本和检测体系建议做梯度优化。

ELISA ELISA 推荐条件
推荐稀释 请参考验证图说明或咨询技术支持
建议样本/阳性对照 建议选择靶点高表达样本作为阳性对照
关键条件 建议从页面推荐浓度开始，结合样本与检测体系做梯度优化
预期结果 预期信号/条带约 36kDa
对照设置 建议设置阳性样本、阴性样本和二抗/同型对照

Immunogen

Immunogen Please contact Support
Sequence Email For Sequence

Target data

Background Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464)
Gene ID 3134
Gene name Ighg1
Swiss P01868
Synonym IgG1 (YD34110),IgG1 (YD34110) Rabbit mAb,Ighg1,Igh-4

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当前页面标注应用包括 ELISA，建议结合页面验证图和推荐稀释比例进行预实验优化。
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AYD11644