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D-α-Tocopherol Succinate  (Cat.#:AYB26892)

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Cat.#：AYB26892

CAS：4345-03-3

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  • Biological activity

  • Information

Biological activity

Bioactivity D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.
CAS 4345-03-3
Mol.Wt. 530.78
In vitro

D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells.

The accuracy of these methods have not been independently confirmed. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:HEI-OC1 cell line
Concentration:1-20 μM
Incubation Time:24 hours
Result:Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.

Cell Viability Assay

Cell Line:HEI-OC1 cell line
Concentration:10 μM
Incubation Time:48 hours
Result:Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.

Cell Cytotoxicity Assay

Cell Line:TC-1 tumor cells
Concentration:0, 25 and 50 μM
Incubation Time:18 hours
Result:Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
Format Solid
Transportation Room temperature in continental US; may vary elsewhere.
Solubility
In Vitro: 

DMSO : 250 mg/mL (471.00 mM; Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.8840 mL9.4201 mL18.8402 mL
5 mM0.3768 mL1.8840 mL3.7680 mL
10 mM0.1884 mL0.9420 mL1.8840 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
Purity ≥98.0%

Information

Intro D-α-Tocopherol Succinate (Vitamin E succinate) 是一种抗氧化生育酚，是维生素 E 的一种盐形式。D-α-Tocopherol Succinat 抑制 Cisplatin (HY-17394) 引起的毒性。D-α-Tocopherol Succinate 可用于癌症的研究。
Synonym Vitamin E succinate
AYB26892