Cremophor EL (Cat.#:AYB26664)
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Biological activity
Information
Biological activity
| Bioactivity | Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of drugs. |
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| CAS | 61791-12-6 |
| Chinese name | 聚氧乙烯蓖麻油EL |
| In vitro | Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment. The accuracy of these methods have not been independently confirmed. They are for reference only. |
| Format | Viscous liquid |
| Transportation | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light |
| Solubility | In Vitro: Ethanol : 50 mg/mL (Need ultrasonic) H2O : 25 mg/mL (Need ultrasonic) |
| Purity | 99.52% |
Information
| Intro | Cremophor EL 是一种聚氧乙烯蓖麻油衍生物，是一种非离子表面活性剂。Cremophor EL 被广泛用于改善药物的溶解和输送。 |
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| Synonym | 聚氧乙烯蓖麻油EL |