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CD27 (YD14413) Rabbit mAb  (Cat.#:AYD15310)

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Host: RabbitClonality: MonoclonalReactivity: MouseIHC-P
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Cat.# AYD15310
Target / gene Cd27
Host Rabbit
Clonality Monoclonal
Reactivity Mouse
Application IHC-P

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Cat.#：AYD15310

SizePrice
50ul RMB: 680Sale1280 Add to cart
100ul RMB: 1219Sale2300 Add to cart

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  • Information

  • Application guide

  • Immunogen

  • Target data

  • Resources

  • FAQs

Reactivity Mouse
Host Rabbit
Clonality Monoclonal
Isotype IgG
Application IHC-P
Dilution
Predicted MW 28kDa
Observed MW
Format Liquid
Storage Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3.
Conjugate Unconjugated
Positive Thymus,Spleen
Subcellular Cell membrane
Purification 亲和纯化

Applications and conditions

Where to start

These starting conditions come from the recommended dilution, validation images, and general assay practice. Titrate for your sample and detection system.

IHC-P Conditions for IHC-P
Recommended dilution See the validation images or contact technical support
Suggested sample / positive control Thymus,Spleen
Key conditions For paraffin sections, optimize retrieval buffer pH, retrieval time, and primary incubation
Expected result Expected localization: Cell membrane
Controls Include a positive sample, a negative sample, and a secondary or isotype control

Immunogen

Immunogen Please contact Support
Sequence Request sequence

Target data

Background Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:11062504). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (By similarity). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (PubMed:15723067). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (PubMed:38386557)
Gene ID 3134
Gene name Cd27
Swiss P41272
Synonym CD27 (YD14413),CD27 (YD14413) Rabbit mAb,Cd27,CD27L receptor,T-cell activation antigen CD27,Tumor necrosis factor receptor superfamily member 7,Tnfrsf7

Resources

Validation data

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References

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FAQs

Listed applications: IHC-P. Use the validation images and recommended dilution as a starting point.
Send the catalog number and lot through the inquiry form. Support will help with the lot documents.
Use the recommended conditions as a starting concentration. Sample, fixation, and detection system may need a titration.
AYD15310