BAPTA-AM (Cat.#:AYB26665)
Biological activity
Information
Biological activity
| Bioactivity | BAPTA-AM is a well-known membrane permeable Ca2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. | ||||||||||||||||
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| CAS | 126150-97-8 | ||||||||||||||||
| Mol.Wt. | 764.68 | ||||||||||||||||
| In vitro | BAPTA-AM inhibits neuronal Ca2+-activated K+ channel currents, and up-regulates the decreased cardiac sodium current (INa) density by chelating intracellular Ca2+. The accuracy of these methods have not been independently confirmed. They are for reference only. |
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| Format | Solid | ||||||||||||||||
| Transportation | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| Solubility | In Vitro: DMSO : 50 mg/mL (65.39 mM; Need ultrasonic) H2O : (insoluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。 |
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| Purity | 99.62% |
Information
| Intro | BAPTA-AM 是一种可透过细胞膜的钙螯合剂 (Ca2+ chelator)。在 HEK 293 细胞中,BAPTA-AM 阻断 hERG,hKv1.3 和 hKv1.5 通道,IC50 分别为 1.3,1.45 和 1.23 μM。 |
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| Rela_targets | Bioactive Compound Library Plus Membrane Transporter/Ion Channel Compound Library Anti-Cardiovascular Disease Compound Library Anti-Alzheimer's Disease Compound Library Neurodegenerative Disease-related Compound Library Potassium Channel Compound Library Human Metabolite Library Membrane Protein-targeted Compound Library Membrane Receptor-targeted Compound Library |
