Arachidonoyl Thio-PC (Cat.#:AYB28379)
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Biological activity
Information
Biological activity
| Bioactivity | Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay. |
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| CAS | 146797-82-2 |
| Mol.Wt. | 784.16 |
| Transportation | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Information
| Intro | Arachidonoyl Thio-PC 是许多磷脂酶 A2 (PLA2) 的底物，包括 sPLA2、cPLA2 和 iPLA2。 PLA2 对 sn-2 脂肪酸的裂解导致游离硫醇的产生，该游离硫醇与显色剂如 DTNB（埃尔曼试剂）和 DTP 反应，从而可以对 PLA2 活性进行定量。可以通过排除或抑制测定中的 sPLA2 和 iPLA2 活性来测量同工酶特异性 cPLA2 活性。 |
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| Synonym | Thiopc |