5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (Cat.#:AYB26930)
Biological activity
Information
Biological activity
| Bioactivity | 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks. | ||||||||||||||||
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| CAS | 23669-79-6 | ||||||||||||||||
| Chinese name | 保护-2'-脱氧尿苷 | ||||||||||||||||
| Mol.Wt. | 530.57 | ||||||||||||||||
| Format | Solid | ||||||||||||||||
| Transportation | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| Storage | 4°C, protect from light | ||||||||||||||||
| Solubility | In Vitro: DMSO : 100 mg/mL (188.48 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。 |
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| Purity | 98.20% |
Information
| Intro | 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) 是一种竞争性的大肠杆菌 dUTP 核苷酸水解酶 (dUTPase) 抑制剂,Ki 值高于 1000 μM。5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine 通过合成核苷亚磷酰胺嵌段用于机器辅助的 DNA 合成。 |
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| Synonym | 5'-O-DMT-dU,保护-2'-脱氧尿苷 |
| Rela_targets | Covalent Screening Library Plus Bioactive Compound Library Plus Cell Cycle/DNA Damage Compound Library Anti-Aging Compound Library Covalent Screening Library Nucleotide Compound Library Heterocyclic Compound Library |
