目录号:B28067
生物活性: trans-11-Eicosenoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 62322-84-3
中文名称:反11-二十碳烯酸
目录号:B28072
生物活性: 8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandins, leukotriene biosynthesis and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenation The enzyme (COX) and 5-lipoxygenase (5-LO) IC50 values were 0.46 μM, 14 μM and 25 μM, respectively. In addition, it inhibits the action of slow-reacting substances of allergic reactions with IC50 values of 10 μM [1,2]. Lipoxygenase is widely found in fungi, plants and animals, and its content is very high. 12-LO is involved in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and various other NSAIDs, making them clinically important [3]. 5-LO is involved in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization. In vitro: As of now, in vitro studies of 8,11,14-eicosatriynoic acid are still under development. In vivo: To date, in vivo studies of 8,11,14-eicosatriynoic acid are in the development stage. References: [1]. Goetz, J., Sprecher, H., Cornwell, D. and Panganamala, R . Inhibition of prostaglandin biosynthesis by triynoic acid. . prostaglandins. 1976;12(2):187-192. [2]. Sun, F., McGuire, J., Morton, D., Pike, J., Sprecher, H. and Kunau, W. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds effect. prostaglandins. 1981;21(2):333-343. [3]. Fitzpatrick, F. Cyclooxygenase: regulation and function. Current Drug Design. 2004;10(6):577-588.
CAS: 34262-64-1
目录号:B27122
生物活性: (Z)-Methyl icos-11-enoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 2390-09-2
中文名称:11C-二十碳烯酸甲酯
目录号:B28038
生物活性: omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
CAS: 123940-93-2
中文名称:(8Z,11Z,14Z,17Z)-ICOSA-8,11,14,17-四烯酸乙酯
目录号:B28330
生物活性: Dehydroergosterol is a naturally occurring fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes. [1] It is readily bound by cholesterol-binding proteins and has been used to probe the sterol environment in real time and elucidate intracellular sterol transport in organisms. [1] References: [1]. McIntosh, AL, Atshaves, BP, Huang, H., et al. A Fluorescent Technique to Study Cholesterol Transport Using Dehydroergosterol. Lipids 43(12), 1185-1208 (2008).
CAS: 516-85-8
中文名称:去氢麦角甾醇
目录号:B28305
生物活性: Lesquerolic acid methyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 4102-96-9
目录号:B26683
生物活性: Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor.
CAS: 9003-11-6
中文名称:泊洛沙姆 407
目录号:B26774
生物活性: Neocuproine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 484-11-7
中文名称:2,9-二甲基-1,10-菲咯啉
目录号:B26856
生物活性: Succinic anhydride, (2-dodecenyl)- (8CI) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
CAS: 19780-11-1
中文名称:2-十二烷烯-1-基丁二酸酐
目录号:B26937
生物活性: β-Galactosidase is a glycoside hydrolase that hydrolyzes the β-glycosidic bonds formed between galactose and its organic moieties. In E.coli, the lacZ gene is the structural gene of β-galactosidase, which can be used as part of the induction system lac operon. β-Galactosidase can hydrolyze lactose to form glucose and galactose, and enter glycolysis; it can also catalyze the transgalactosylation of lactose into allolactose; allolactose can be cracked into monosaccharides.
CAS: 9031-11-2
