VEGF Receptor 2 (YD20041) Rabbit mAb (货号:AYD12825)
A
小A
销售顾问
请使用微信扫一扫
添加顾问进行咨询
暂无验证图
欢迎提交实验图片，或联系 技术支持 获取更多信息。
产品信息
相关产品
抗原信息
靶点信息
| 反应 | Mouse |
|---|---|
| 宿主 | Rabbit |
| 克隆性 | Monoclonal |
| 应用 | ICC/IFFC |
| 推荐浓度 | |
| 理论分子量 | 150kDa |
| 实测分子量 | |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3. |
| 偶联物 | Unconjugated |
| 阳性对照 | |
| 细胞定位 | Cell junction, Endoplasmic reticulum, Cell membrane, Cytoplasm, Nucleus, Cytoplasmic vesicle, Early endosome, Secreted |
| 纯化 |
相关产品
查找相关产品 >>
抗原信息
| 抗原信息 | 请咨询 技术支持 |
|---|---|
| 序列 | Email For Sequence |
靶点信息
| 研究背景 | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and by preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC |
|---|---|
| 基因 ID | 3134 |
| 基因名 | Kdr |
| Swiss | P35918 |
| 别名 | VEGF Receptor 2 (YD20041) |