Taurohyodeoxycholic acid sodium (货号:AYB27206)
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生物活性
产品信息
生物活性
| 生物活性 | Taurohyodeoxycholic acid sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. 1 THDCA reduces the size and weight of human gallstones in vitro. It increases bile flow, bile cholesterol secretion and bile lipid secretion in rats. 2 Co-administration of THDCA and taurochenodeoxycholic acid prevented TCDCA-induced hepatotoxicity and increased bile flow and bile acid and phospholipid secretion in rats. 3 THDCA can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model. 41. Angelico, M., Mogavero, L., Baiocchi, L., et al. Dissolution of human cholesterol bile salts/lecithin mixtures for gallstones: effects of bile salt hydrophobicity and various pHsScand. J. Gastroenterol.30(12)1178-1185(1995) 2.Angelico, M., Baiocchi, L., Nistri, A., et al.Effect of taurohodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid 2. Angelico, M., Baiocchi, L., Nistri, A., et al. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretions in rats. Sci.39(11)2389-2397(1994) 3.Roda, A., Piazza, F., Baraldini, M., et al.Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rataHepatology27(2)520-525 (1998) 4.He, J., Liang, J., Zhu, S., et al. Protective effect of pig powder taurine hyodeoxycholic acid on trinitrobenzenesulfonic acid-induced ulcerative colitis in mice Eur . J. Pharmacol. 670(1) 229-235(2011) |
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| CAS | 38411-85-7 |
| 中文名称 | 牛磺猪去氧胆酸钠(SIGMA分装) |
| 分子量 | 521.69 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 保存条件 | Please store the product under the recommended conditions in the Certificate of Analysis. |
产品信息
| Intro | Taurohyodeoxycholic acid sodium 是次级胆汁酸猪脱氧胆酸的牛磺酸结合形式。1 THDCA 可在体外减小人胆结石的大小和重量。它增加大鼠的胆汁流量、胆汁胆固醇分泌和胆汁脂质分泌。2 THDCA 与牛磺鹅脱氧胆酸的共同给药可防止 TCDCA 诱导的肝毒性，增加大鼠的胆汁流量以及胆汁酸和磷脂分泌。3 THDCA 还可以降低髓过氧化物酶TNF-α 和 IL-6 的活性、表达以及 TNBS 诱导的溃疡性结肠炎小鼠模型中的结肠损伤。41.Angelico, M., Mogavero, L., Baiocchi, L., et al.Dissolution of human cholesterol胆汁盐/卵磷脂混合物中的胆结石：胆汁盐疏水性和各种 pHsScand 的影响。 J. Gastroenterol.30(12)1178-1185(1995) 2.Angelico, M., Baiocchi, L., Nistri, A., et al.Effect of taurohodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid 2.Angelico, M., Baiocchi, L., Nistri, A., et al.Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid 信息来源大鼠体内的分泌物迪斯。 Sci.39(11)2389-2397(1994) 3.Roda, A., Piazza, F., Baraldini, M., et al.Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rataHepatology27(2)520-525 (1998) 4.He, J., Liang, J., Zhu, S., et al. 猪粉牛磺猪脱氧胆酸对三硝基苯磺酸诱导的小鼠溃疡性结肠炎的保护作用Eur。 J. Pharmacol.670(1)229-235(2011) |
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| 别名 | Taurohyodeoxycholic acid sodium salt hydrate |