SYNPO2 Rabbit pAb  (货号:B19561)

说明书

货号:B19561

规格价格
50ul ¥1080.00 加购物车
100ul ¥2050.00 加购物车
反应 Mouse
宿主 Rabbit
克隆性 Polyclonal
应用 WB
推荐浓度 WB: 1:500 - 1:1000
理论分子量 74kDa/117kDa/119kDa/133kDa/136kDa
实测分子量 117kDa
形式 Liquid
保存条件 Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
偶联物 Unconjugated
阳性对照 Mouse skeletal muscle
细胞定位 Cytoplasm,Nucleus
纯化 Affinity purification

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抗原信息

抗原信息 Recombinant fusion protein.
序列 Email For Sequence

靶点信息

研究背景 Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity. Involved in regulation of cell migration. May be a tumor suppressor.
基因ID 171024
基因名 SYNPO2
Swiss Q9UMS6
别名 SYNPO2
组织表达 Expressed in heart muscle. Isoform 5 is specifically expressed in skeletal muscle.
功能 Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).
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