STING/TMEM173 Rabbit mAb (货号:AYT1001)
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Western blot analysis of STING/TMEM173 expressed in Mouse spleen,Rat thymus,THP-1 using STING/TMEM173 Rabbit pAb at 1:1000. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:5000. Lysates/proteins: 30ug per lane. Blocking buffer: 5% non-fat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 120s.
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Western blot - STING/TMEM173 Rabbit pAb
Western blot analysis of STING/TMEM173 expressed in Mouse spleen,Rat thymus,THP-1 using STING/TMEM173 Rabbit pAb at 1:1000. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:5000. Lysates/proteins: 30ug per lane. Blocking buffer: 5% non-fat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 120s.
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靶点信息
| 反应 | |
|---|---|
| 宿主 | |
| 克隆性 | |
| 应用 | |
| 推荐浓度 | WB: 1:1000 - 1:3000 IHC: 1:100 - 1:800 IF/ICC: 1:100 - 1:800 IP: IP 1:50-1:200 ELISA : 1:5000-1:20000 |
| 理论分子量 | 42kDa |
| 实测分子量 | 40KDa |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
| 偶联物 | |
| 阳性对照 | THP-1,Mouse spleen,Mouse thymus,Rat thymus,Rat lung |
| 细胞定位 | Cell membrane,Cytoplasm,Endoplasmic reticulum membrane,Mitochondrion outer membrane,Multi-pass membrane protein,perinuclear region |
| 纯化 | purified via Protein A affinity chromatography. |
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抗原信息
| 抗原信息 | 请咨询 技术支持 |
|---|---|
| 序列 |
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靶点信息
| 研究背景 | This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. |
|---|---|
| 基因 ID | 340061 |
| 基因名 | TMEM173 |
| Swiss | Q86WV6 |
| 别名 | TMEM173;ERIS;MITA;MPYS;NET23;SAVI;STING;hMITA;hSTING |
| 组织表达 | Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. |
| 功能 | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). |
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