Phosphatidylglycerols, egg, sodium salts (货号:AYB28054)
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生物活性
产品信息
生物活性
| 生物活性 | Phosphatidylglycerol is a naturally occurring anionic phospholipid that is a component of plant, animal and bacterial cell membranes. It is present in prokaryotes and eukaryotes less than phosphatidylethanolamine, and in eukaryotes less than phosphatidylcholine. It is formed by the reaction between CDP-diglyceride and L-α-glycerol 3-phosphate followed by dephosphorylation and is the metabolic precursor of cardiolipin. Phosphatidylglycerols containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote the proliferation of murine keratinocytes, respectively. Phosphatidylglycerol is the second-largest lipid component of mammalian lung surfactant, accounting for 10% of lipids, and has reduced levels of pulmonary surfactant in infants with respiratory distress syndrome. Phosphatidylglycerol (egg) is a mixture of phosphatidylglycerols isolated from eggs with various fatty acyl groups at the sn-1 and sn-2 positions. References: [1]. Ohtsuka, T., Nishijima, M., and Akamatsu, Y. Phosphatidylglycerol phosphate synthase-deficient somatic mutants with impaired phosphatidylglycerol and cardiolipin biosynthesis J. Biol. Chemical. 268(30), 22908-22913 (1993).[2]. Furse, S. Are phosphatidylglycerols essential for terrestrial life? J. Chemistry. biology. 10(1), 1-9 (2016).[3]. Xie, D., Seremwe, M., Edwards, JG, et al. Different effects of different phosphatidylglycerols on the proliferation of mouse keratinocytes PLoS One 9(9), e107119 (2014). |
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| CAS | 383907-64-0 |
| 中文名称 | 1,2-二酰基-SN-甘油-3-磷酸-[1-RAC-甘油] |
| 形式 | Solid |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 保存条件 | 4°C, sealed storage, away from moisture |
产品信息
| Intro | 磷脂酰甘油是一种天然存在的阴离子磷脂，是植物、动物和细菌细胞膜的组成部分。它在原核生物和真核生物中的含量低于磷脂酰乙醇胺，在真核生物中的含量低于磷脂酰胆碱。它是通过 CDP-甘油二酯与 L-α-甘油 3-磷酸之间的反应然后去磷酸化形成的，是心磷脂的代谢前体。含有多不饱和和单不饱和脂肪酰基链的磷脂酰甘油分别抑制和促进鼠角质形成细胞的增殖。磷脂酰甘油是哺乳动物肺表面活性物质的第二大脂质成分，占脂质的 10%，并且在患有呼吸窘迫综合征的婴儿的肺表面活性物质中水平降低。磷脂酰甘油（蛋）是从蛋中分离出来的磷脂酰甘油的混合物，在 sn-1 和 sn-2 位置具有各种脂肪酰基。参考文献：[1]。 Ohtsuka, T.、Nishijima, M. 和 Akamatsu, Y. 磷脂酰甘油磷酸合酶缺陷的体细胞突变体，磷脂酰甘油和心磷脂生物合成受损 J. Biol。化学。 268(30), 22908-22913 (1993).[2]。 Furse, S. 磷脂酰甘油对陆地生命至关重要吗？ J.化学。生物学。 10(1), 1-9 (2016).[3]。 Xie, D., Seremwe, M., Edwards, JG, 等人。不同磷脂酰甘油对小鼠角质形成细胞增殖的不同影响 PLoS One 9(9), e107119 (2014)。 |
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| 别名 | Phosphatidylglycerols (egg) (sodium salt) |