Mast Cell Tryptase (YD12112) Rabbit mAb (货号:AYD15818)
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货号
AYD15818
靶点/基因
TPSAB1
宿主
Rabbit
克隆性
Monoclonal
反应种属
Human
应用
IHC-P
暂无验证图
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产品信息
应用指南
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抗原信息
靶点信息
资料与支持
常见问题
| 反应 | Human |
|---|---|
| 宿主 | Rabbit |
| 克隆性 | Monoclonal |
| 同种型 | IgG |
| 应用 | IHC-P |
| 推荐浓度 | |
| 理论分子量 | 31kDa |
| 实测分子量 | |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3. |
| 偶联物 | Unconjugated |
| 阳性对照 | Mouse skin,Rat skin |
| 细胞定位 | Secreted |
| 纯化 | 亲和纯化 |
应用与推荐条件
快速判断怎么用
以下条件基于推荐浓度、验证图说明与通用实验要求整理，可作为预实验起点；不同样本和检测体系建议做梯度优化。
IHC-P
IHC-P 推荐条件
| 推荐稀释 | 请参考验证图说明或咨询技术支持 |
|---|---|
| 建议样本/阳性对照 | Mouse skin,Rat skin |
| 关键条件 | 石蜡切片建议优化抗原修复液 pH、修复时间和一抗孵育条件 |
| 预期结果 | 预期定位：Secreted |
| 对照设置 | 建议设置阳性样本、阴性样本和二抗/同型对照 |
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抗原信息
| 抗原信息 | 请咨询 技术支持 |
|---|---|
| 序列 | Email For Sequence |
靶点信息
| 研究背景 | Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. |
|---|---|
| 基因 ID | 7177 |
| 基因名 | TPSAB1 |
| Swiss | Q15661 |
| 别名 | Mast Cell Tryptase (YD12112),Mast Cell Tryptase (YD12112) Rabbit mAb,TPSAB1,Tryptase I,Tryptase alpha-1,TPS1,TPS2,TPSB1 |
资料与技术支持
验证数据
欢迎联系技术支持获取验证图与应用案例。
常见问题
当前页面标注应用包括 IHC-P，建议结合页面验证图和推荐稀释比例进行预实验优化。
可通过页面询价/留言入口提交货号和批号，技术支持会协助提供对应批次资料。
页面推荐条件可作为起始浓度，不同样本、固定方式和检测体系可能需要梯度优化。