MBNL1 Rabbit mAb  (货号:B30806)

说明书

货号:B30806

规格价格
50ul ¥1080.00 加购物车
100ul ¥2050.00 加购物车
反应 Human,Mouse
宿主 Rabbit
克隆性 Monoclonal
应用 WB
推荐浓度 WB: 1:500 - 1:2000
理论分子量 33kDa/34kDa/36kDa/37kDa/39kDa/40kDa/41kDa
实测分子量 40kDa
形式 Liquid
保存条件 Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3.
偶联物 Unconjugated
阳性对照 Jurkat,HepG2,MCF7
细胞定位 Cytoplasm,Cytoplasmic granule,Nucleus
纯化 Affinity purification

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抗原信息

抗原信息 Recombinant fusion protein.
序列 Email For Sequence

靶点信息

研究背景 This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
基因ID 4154
基因名 MBNL1
Swiss Q9NR56
别名 MBNL1;EXP;MBNL
组织表达 Highly expressed in cardiac, skeletal muscle and during myoblast differentiation. Weakly expressed in other tissues (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
功能 Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
研究领域

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