LRP6 Rabbit mAb  (货号:B28851)

说明书

货号:B28851

规格价格
50ul ¥1080.00 加购物车
100ul ¥2050.00 加购物车
反应 Human,Mouse,Rat
宿主 Rabbit
克隆性 Monoclonal
应用 WBIF/ICCFC
推荐浓度 WB: 1:500 - 1:2000
IF/ICC: 1:50 - 1:200
FC: 1:20 - 1:50
理论分子量 180kDa
实测分子量 180-230kDa
形式 Liquid
保存条件 Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3.
偶联物 Unconjugated
阳性对照 Mouse liver
细胞定位 Endoplasmic reticulum,Membrane,Single-pass type I membrane protein
纯化 Affinity purification

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抗原信息

抗原信息 Recombinant fusion protein.
序列 Email For Sequence

靶点信息

研究背景 This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
基因ID 4040
基因名 LRP6
Swiss O75581
别名 LRP6;ADCAD2;STHAG7
组织表达 Widely coexpressed with LRP5 during embryogenesis and in adult tissues.
功能 Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
研究领域

实验步骤

实验步骤

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