HCoV-NL63 Spike S2 Rabbit pAb  (货号:B17991)

说明书

货号:B17991

规格价格
50ul ¥1080.00 加购物车
100ul ¥2050.00 加购物车
反应 HCoV-NL63
宿主 Rabbit
克隆性 Polyclonal
应用 WB
推荐浓度 WB: 1:500 - 1:1000
理论分子量 149kDa
实测分子量 160KDa
形式 Liquid
保存条件 Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
偶联物 Unconjugated
阳性对照 Human coronavirus (HCoV-NL63) Spike Protein (S1+S2 ECDHis Tag)
细胞定位
纯化 Affinity purification

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抗原信息

抗原信息 Recombinant fusion protein.
序列 Email For Sequence

靶点信息

研究背景 S1 region attaches the virion to the cell membrane by interacting with host ACE2, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
基因ID 2943499
基因名
Swiss Q6Q1S2
别名

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