Ganglioside GM2, Asialo (货号:AYB27267)
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生物活性
产品信息
生物活性
| 生物活性 | Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length. |
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| CAS | 35960-33-9 |
| 中文名称 | GA2神经节苷脂 |
| 分子量 | 1093.43 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 保存条件 | Please store the product under the recommended conditions in the Certificate of Analysis. |
产品信息
| Intro | 神经节苷脂 GM2 asialo (asialo-GM2) 是一种糖鞘脂，含有三个单糖残基和一个链长可变的脂肪酸，但缺少神经节苷脂 M2 上存在的唾液酸残基。 Asialo-GM2 在正常人脑中的水平很低，甚至检测不到，但它会在泰-萨克斯病和桑德霍夫病患者的大脑中积累，这两种疾病是分别以溶酶体 β-己糖胺酶 A 和 B 缺乏为特征的神经退行性疾病。它还与各种细菌结合，包括从囊性纤维化患者分离出的假单胞菌。 Asialo-GM2 混合物包含神经节苷脂 GM2 asialo 分子种类，具有可变长度的脂肪酰链。 |
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| 别名 | Gangliotriosylceramide |