| 生物活性 | EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages. |
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| CAS | 13368-13-3 |
| 中文名称 | |
| 分子量 | 468.28 |
| 体外研究 | EGTA tetrasodium, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA tetrasodium concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules. The accuracy of these methods have not been independently confirmed. They are for reference only. |
| 体内研究 | |
| 形式 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 保存条件 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 说明书 |
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