| 生物活性 | EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages. | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAS | 67-42-5 | ||||||||||||||||
| 中文名称 | |||||||||||||||||
| 分子量 | 380.35 | ||||||||||||||||
| 体外研究 | EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules. The accuracy of these methods have not been independently confirmed. They are for reference only. |
||||||||||||||||
| 体内研究 | |||||||||||||||||
| 形式 | Solid | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 保存条件 | |||||||||||||||||
| 溶解性 | In Vitro: H2O : 5 mg/mL (13.15 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C) DMSO : 1 mg/mL (2.63 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
| 纯度 | ≥98.0% |
|---|---|
| 说明书 |
暂无数据
