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D-α-Tocopherol Succinate
D-α-Tocopherol Succinate (货号:B26892)
| 规格 | 价格 | |
|---|
| Free Sample (0.1 - 0.2 mg) |
|
询价
|
| 1 g |
|
询价
|
| 5 g |
|
询价
|
| 100 mg |
￥400.00 |
加购物车
|
| 250 mg |
￥600.00 |
加购物车
|
| 500 mg |
￥760.00 |
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|
| 生物活性 |
D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer. |
| CAS |
4345-03-3 |
| 中文名称 |
|
| 分子量 |
530.78 |
| 体外研究 |
D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells.
D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity.
D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells. The accuracy of these methods have not been independently confirmed. They are for reference only. Cell Cytotoxicity Assay | Cell Line: | HEI-OC1 cell line | | Concentration: | 1-20 μM | | Incubation Time: | 24 hours | | Result: | Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM. |
Cell Viability Assay | Cell Line: | HEI-OC1 cell line | | Concentration: | 10 μM | | Incubation Time: | 48 hours | | Result: | Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis. |
Cell Cytotoxicity Assay | Cell Line: | TC-1 tumor cells | | Concentration: | 0, 25 and 50 μM | | Incubation Time: | 18 hours | | Result: | Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells. |
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| 体内研究 |
|
| 形式 |
Solid |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 保存条件 |
|
| 溶解性 |
In Vitro: DMSO : 250 mg/mL (471.00 mM; Need ultrasonic) 配制储备液 | 1 mM | 1.8840 mL | 9.4201 mL | 18.8402 mL | | 5 mM | 0.3768 mL | 1.8840 mL | 3.7680 mL | | 10 mM | 0.1884 mL | 0.9420 mL | 1.8840 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 |
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