Citric acid monohydrate  (货号:B26966)

说明书
Citric acid monohydrate
规格价格
50 g 询价
5 g ￥200.00 加购物车
10 g ￥350.00 加购物车

货号：B26966

生物活性 Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice.
CAS 5949-29-1
中文名称 一水柠檬酸
分子量 210.14
体外研究

Citric acid monohydrate (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.
Citric acid monohydrate (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.
Citric acid monohydrate (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl.

The accuracy of these methods have not been independently confirmed. They are for reference only.

Cell Viability Assay

Cell Line:HaCaT cells
Concentration:0, 2.5, 5, 7.5, 10, 12.5 mM
Incubation Time:24 h
Result:Inhibited the cell viability in a dose dependent manner.

Cell Cycle Analysis

Cell Line:HaCaT cells
Concentration:12.5 mM
Incubation Time:0, 12, 24, 48, 72 h
Result:Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.

Western Blot Analysis

Cell Line:HaCaT cells
Concentration:12.5 mM
Incubation Time:12, 24, 48 h
Result:Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
体内研究
形式 Solid
运输条件 Room temperature in continental US; may vary elsewhere.
保存条件 4°C, sealed storage, away from moisture
溶解性

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