Cholesterol 5beta,6beta-epoxide (货号:AYB27704)
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生物活性
产品信息
生物活性
| 生物活性 | Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. [1] [2] Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. [3] 5β,6β-epoxycholestanol has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue. [4] References: [1]. Pulfer, MK, and Murphy, RC Formation of bioactive oxygen sterols during ozonolysis of cholesterol present in lung surfactants. Journal of Biochemistry 279(25), 26331-26338 (2004). [2]. Aringer, L. and Eneroth, P. In vitro formation and metabolism of cholesterol and β-sitosterol 5,6-epoxides. J. Lipid Research. 15(4), 389-398 (1974).[3]. Lordan, S., O'Brien, NM, and Mackrill, JJ Calcium in 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide-induced apoptosis. J. Biochemistry. Moore. poison. 23(5), 324-332 (2009).[4]. Garcia-Cruset, S., Carpenter, KL, Guardiola, F. et al. Oxysterol profiles of normal human arteries, fatty streaks, and advanced lesions. free radicals. reservoir. 35(1), 31-41 (2001). |
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| CAS | 4025-59-6 |
| 中文名称 | 5Β,6Β-环氧胆甾醇 |
| 分子量 | 402.65 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 保存条件 | Please store the product under the recommended conditions in the Certificate of Analysis. |
产品信息
| Intro | Cholesterol 5beta,6beta-epoxide 是胆固醇的一种氧化代谢物，通过胆固醇在 5,6 双键处的自由基和非自由基氧化形成。 [1] [2] 在巨噬细胞分化的 U937 细胞中诱导乳酸脱氢酶 (LDH) 的释放和细胞凋亡。 [3] 5β,6β-环氧胆甾烷醇已在人类脂肪条纹和晚期动脉粥样硬化病变中发现，但不存在于正常主动脉组织中。 [4]参考文献：[1]。 Pulfer, MK, and Murphy, RC 在肺表面活性剂中存在的胆固醇臭氧分解过程中生物活性氧固醇的形成。生物化学杂志 279(25), 26331-26338 (2004). [2]. Aringer, L. 和 Eneroth, P. 胆固醇和 β-谷甾醇 5,6-环氧化物的体外形成和代谢。 J. 脂质研究。 15(4), 389-398 (1974).[3]。 Lordan, S.、O'Brien, NM 和 Mackrill, JJ 钙在 7β-羟基胆固醇和胆固醇-5β,6β-环氧化物诱导的细胞凋亡中的作用。 J. 生物化学。摩尔。毒物。 23(5), 324-332 (2009).[4]。 Garcia-Cruset, S.、Carpenter, KL、Guardiola, F. 等。正常人动脉、脂肪条纹和晚期病变的氧固醇概况。自由基。水库。 35(1), 31-41 (2001)。 |
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| 别名 | Cholesterol beta-epoxide |