CAR/CXADR Rabbit pAb  (货号:B17958)

说明书

货号:B17958

规格价格
50ul ¥1080.00 加购物车
100ul ¥2050.00 加购物车
反应 Human,Mouse,Rat
宿主 Rabbit
克隆性 Polyclonal
应用 WB
推荐浓度 WB: 1:500 - 1:1000
理论分子量 9kDa/22kDa/28kDa/35kDa/38kDa/40kDa
实测分子量 50KDa
形式 Liquid
保存条件 Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
偶联物 Unconjugated
阳性对照 U-251MG,Mouse kidney
细胞定位 Basolateral cell membrane,Cell junction,Cell membrane,Secreted,Single-pass membrane protein,Single-pass type I membrane protein,Single-pass type I membrane protein,adherens junction,tight junction
纯化 Affinity purification

相关产品

查找相关产品 >>

抗原信息

抗原信息 Recombinant fusion protein.
序列 Email For Sequence

靶点信息

研究背景 The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.
基因ID 1525
基因名 CXADR
Swiss P78310
别名 CXADR;CAR;CAR4/6;HCAR
组织表达 Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
功能 Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
研究领域

实验步骤

实验步骤

文献引用

暂无数据

客户评价

未选文件 允许的格式:jpg,png 每张图片最大1M,支持多选
5星

CAR/CXADR Rabbit pAb 有 0 条评价