ACVR1 Rabbit mAb  (货号:B30729)

说明书

货号:B30729

规格价格
50ul ¥1080.00 加购物车
100ul ¥2050.00 加购物车
反应 Human,Mouse,Rat
宿主 Rabbit
克隆性 Monoclonal
应用 WBIP
推荐浓度 WB: 1:500 - 1:2000
IP: 1:20 - 1:50
理论分子量 57kDa
实测分子量 57kDa
形式 Liquid
保存条件 Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.75% BSA,50% glycerol,pH7.3.
偶联物 Unconjugated
阳性对照 293T,A-549,MCF7,Mouse brain,Rat testis,Rat brain
细胞定位 Membrane,Single-pass type I membrane protein
纯化 Affinity purification

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抗原信息

抗原信息 Recombinant fusion protein.
序列 Email For Sequence

靶点信息

研究背景 Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
基因ID 90
基因名 ACVR1
Swiss Q04771
别名 ACVR1; ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI; activin receptor type-1
组织表达 Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
功能 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
研究领域

实验步骤

实验步骤

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