8,11,14-Eicosatriynoic Acid (货号:AYB28072)
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生物活性
产品信息
生物活性
| 生物活性 | 8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandins, leukotriene biosynthesis and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenation The enzyme (COX) and 5-lipoxygenase (5-LO) IC50 values were 0.46 μM, 14 μM and 25 μM, respectively. In addition, it inhibits the action of slow-reacting substances of allergic reactions with IC50 values of 10 μM [1,2]. Lipoxygenase is widely found in fungi, plants and animals, and its content is very high. 12-LO is involved in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and various other NSAIDs, making them clinically important [3]. 5-LO is involved in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization. In vitro: As of now, in vitro studies of 8,11,14-eicosatriynoic acid are still under development. In vivo: To date, in vivo studies of 8,11,14-eicosatriynoic acid are in the development stage. References: [1]. Goetz, J., Sprecher, H., Cornwell, D. and Panganamala, R . Inhibition of prostaglandin biosynthesis by triynoic acid. . prostaglandins. 1976;12(2):187-192. [2]. Sun, F., McGuire, J., Morton, D., Pike, J., Sprecher, H. and Kunau, W. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds effect. prostaglandins. 1981;21(2):333-343. [3]. Fitzpatrick, F. Cyclooxygenase: regulation and function. Current Drug Design. 2004;10(6):577-588. |
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| CAS | 34262-64-1 |
| 分子量 | 300.44 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 保存条件 | Please store the product under the recommended conditions in the Certificate of Analysis. |
产品信息
| Intro | 8,11,14-Eicosatriynoic Acid，作为前列腺素、白三烯生物合成和花生四烯酸诱导的血小板聚集的抑制剂，可阻断人 12-脂氧合酶 (12-LO)、环氧合酶 (COX) 和 5-脂氧合酶 (5-LO) IC50 值分别为 0.46 μM、14 μM 和 25 μM。此外，它还抑制过敏反应的慢反应物质的作用，IC50 值为 10 μM [1,2]。脂氧合酶广泛存在于真菌、植物和动物中，含量很高。 12-LO 涉及许多重要的疾病状态，并且可能在氧化谷氨酸毒性中起作用。 COX 酶在人体生理学和病理学中发挥着复杂的作用，涉及神经元、免疫、肾脏、心血管、胃肠道和生殖系统。 COX 酶被阿司匹林和多种其他非甾体类抗炎药阻断，这使得它们在临床上很重要 [3]。 5-LO 参与癌症病理学。它由多种癌细胞表达，包括结肠癌、肺癌、乳腺癌和前列腺癌，并促进癌细胞生长和新血管生成。体外：截至目前，8,11,14-二十碳三炔酸的体外研究尚处于开发阶段。体内：截至目前，8,11,14-二十碳三炔酸的体内研究尚处于开发阶段stage.References:[1]. Goetz, J.、Sprecher, H.、Cornwell, D. 和 Panganamala, R. 三炔酸对前列腺素生物合成的抑制作用。前列腺素。 1976年； 12(2)：187-192。 [2]. Sun, F.、McGuire, J.、Morton, D.、Pike, J.、Sprecher, H. 和 Kunau, W. 乙炔酸化合物对血小板花生四烯酸 12-脂氧合酶的抑制作用。前列腺素。 1981; 21(2)：333-343。 [3]. Fitzpatrick, F. 环氧合酶：调节和功能。当前的药物设计。 2004； 10(6)：577-588。 |
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| 别名 | 8,11,14-Icosatriynoic acid |